Dr Matthew Knight

Dr Knight is a Consultant Physician in Respiratory Medicine at West Hertfordshire Hospitals NHS Trust and the Chief Medical Officer and Responsible Officer at Medefer. He sees patients privately with respiratory problems such as breathlessness, cough and chest pain at The Clementine Churchill Hospital in north London and OSD Healthcare in Hemel Hempstead.

Dr Knight has an interest in unexplained breathlessness, and regularly performs cardio-pulmonary exercise testing (CPEX) alongside standard clinical assessment. He is actively involved in research and has published widely over recent years, most latterly around Long Covid, out of hospital management of respiratory diseases and the role of technology in remote care of patients. Along with Dr Andy Barlow and colleagues from NHSX he pioneered some of the early work on Virtual Covid Wards, for which he was made an MBE.

He qualified from University College London in 2005 and undertook respiratory speciality training in the northwest Thames Respiratory training programme, rotating via the Royal Free, Hammersmith, Royal Brompton, Harefield, Barnet, Northwick Park and Watford General hospitals. He also completed a Postgraduate Certificate in Allergy Medicine at Imperial College London.

He is actively involved with the specialist training and education of junior doctors both locally in Watford and previously at a national level with Health Education England where he was an Associate Postgraduate Dean. He sits as a non-executive director on the board of Penrose Care, a registered provider of home care services in northwest London.

Dr Knight manages patients with a wide range of respiratory problems, but has a particular interest in the following areas of Respiratory Medicine:

• Unexplained Breathlessness assessment
• Cardio-Pulmonary Exercise Testing
• Cough and wheeze
• Pleural diseases
• Asthma and Respiratory allergies
• Recurrent chest infections and fever
• Sleep Apnoea
• Lung cancer (diagnosis and screening)
• Chronic Obstructive Pulmonary Disease (COPD)

Dr Knight works closely with his colleagues in the Chest Clinic as well as colleagues in Respiratory Physiology, Cardiology, Physiotherapy, Speech and Language Therapy, Radiology and Thoracic surgery to ensure that patients treated by him receive the best possible care.

Recent publications/media

Dr Knight is actively involved in research, and participates in recruitment to clinical trials in pleural diseases and asthma. ​He was actively involved in early recommendations regarding the care of patients with Post Covid Syndrome.

His researchgate and google scholar profiles contain up to date links to peer reviewed papers and links to some articles and papers are below:​

Digital outpatient health solutions as a vehicle to improve healthcare sustainability—a United Kingdom focused policy and practice perspective 

​Matthew Brown, Matthew Knight, Christopher Peters, Simin Maleki, Ali Motavalli and Bahman Nedjat-Shokouhi.

Front. Digit. Health 2023, Vol 5​

Virtual wards- an account from NHSX">Virtual wards- an account from NHSX

​Feasibility and accuracy of the 40-steps desaturation test to determine outcomes in a cohort of patients presenting to hospital with and without COVID-19

GH Rhys, T Wakeling, SH Moosavi, JP Moore, H Dawes, M Knight, ...

Clinical Medicine 22 (3), 203

Accuracy of Rapid Point-of-Care Antibody Test in patients with suspected or confirmed COVID-19">Accuracy of Rapid Point-of-Care Antibody Test in patients with suspected or confirmed COVID-19

R Vancheeswaran, ML Willcox, B Stuart, M Knight, H Kandil, A Barlow, ...

Journal of Infection 84 (1), 94-118

Post-acute covid-19 in primary care">Post-acute covid-19 in primary care

M Knight, R Vancheeswaran

bmj 375

Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review">Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review

A Kalin, B Javid, M Knight, M Inada-Kim, T Greenhalgh

Systematic reviews 10 (1), 1-13

Racial discrepancies in oximetry: where do we stand?">Racial discrepancies in oximetry: where do we stand?

MJ Knight, CP Subbe, M Inada-Kim

Anaesthesia

Early prognostication of COVID-19 to guide hospitalisation versus outpatient monitoring using a point-of-test risk prediction score">Early prognostication of COVID-19 to guide hospitalisation versus outpatient monitoring using a point-of-test risk prediction score

F Chua, R Vancheeswaran, A Draper, T Vaghela, M Knight, R Mogal, ...

Thorax 76 (7), 696-703

Ambulatory management of secondary spontaneous pneumothorax: a randomised controlled trial">Ambulatory management of secondary spontaneous pneumothorax: a randomised controlled trial

SP Walker, E Keenan, O Bintcliffe, AE Stanton, M Roberts, J Pepperell, ...

European Respiratory Journal 57 (6)

Authors’ reply to Moyle and Ashworth">Authors’ reply to Moyle and Ashworth

M Knight, T Greenhalgh, NJ Fulop, M Inada-Kim

bmj 373

Remote management of covid-19 using home pulse oximetry and virtual ward support">Remote management of covid-19 using home pulse oximetry and virtual ward support

T Greenhalgh, M Knight, M Inda-Kim, NJ Fulop, J Leach, ...

bmj 372

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Long Covid- recommendations and priority research questions">Long Covid- recommendations and priority research questions - a report to the House of Lords Long Covid sub committee.

Predictors of clinical deterioration in patients with suspected COVID-19 managed in a ‘virtual hospital’setting: a cohort study">Predictors of clinical deterioration in patients with suspected COVID-19 managed in a ‘virtual hospital’setting: a cohort study

NA Francis, B Stuart, M Knight, R Vancheeswaran, C Oliver, M Willcox, ...

BMJ open 11 (3), e045356

P256 Prognostication in COVID-19: a prospectively derived and externally validated risk prediction score for in-hospital death">P256 Prognostication in COVID-19: a prospectively derived and externally validated risk prediction score for in-hospital death

F Chua, A Draper, M Knight, R Mogal, J Singh, LG Spencer, E Thwaite, ...

Thorax 76 (Suppl 1), A228-A229

Mobile App–Based Remote Patient Monitoring in Acute Medical Conditions: Prospective Feasibility Study Exploring Digital Health Solutions on Clinical Workload During the COVID crisis">Mobile App–Based Remote Patient Monitoring in Acute Medical Conditions: Prospective Feasibility Study Exploring Digital Health Solutions on Clinical Workload During the COVID crisis

SS Shah, A Gvozdanovic, M Knight, J Gagnon

JMIR formative research 5 (1), e23190

Long COVID: a primer for family physicians">Long COVID: a primer for family physicians

T Greenhalgh, M Knight

American family physician 102 (12), 716-717

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PMD35 Remote Patient Monitoring in ACUTE Medical Conditions; CAN Digital Health Solutions Reduce Clinician Workload and Ease the Pressure on Healthcare Providers during the Covid Crisis">PMD35 Remote Patient Monitoring in ACUTE Medical Conditions; CAN Digital Health Solutions Reduce Clinician Workload and Ease the Pressure on Healthcare Providers during the Covid Crisis

S Shah, A Gvozdanovic, M Knight, J Gagnon

Value in Health 23, S582

What is the Efficacy and Safety of Rapid Exercise Tests for Exertional Desaturation in Covid-19: A Rapid Systematic Review">What is the Efficacy and Safety of Rapid Exercise Tests for Exertional Desaturation in Covid-19: A Rapid Systematic Review

A Kalin, B Javid, M Knight, M Inada-Kim, T Greenhalgh

Predictors of adverse outcome in patients with suspected COVID-19 managed in a ‘virtual hospital’setting: a cohort study">Predictors of adverse outcome in patients with suspected COVID-19 managed in a ‘virtual hospital’setting: a cohort study

NA Francis, B Stuart, M Knight, R Vancheeswaran, C Oliver, M Willcox, ...

Late Breaking Abstract-Randomised trial of ambulatory management of primary spontaneous pneumothorax">Late Breaking Abstract-Randomised trial of ambulatory management of primary spontaneous pneumothorax

R Hallifax, E Mckeown, P Sivakumar, I Fairburn, C Peter, A Leitch, ...

European Respiratory Journal 56 (suppl 64)

Management of post-acute covid-19 in primary care">Management of post-acute covid-19 in primary care

T Greenhalgh, M Knight, M Buxton, L Husain

bmj 370

Ambulatory management of primary spontaneous pneumothorax: an open-label, randomised controlled trial">Ambulatory management of primary spontaneous pneumothorax: an open-label, randomised controlled trial

RJ Hallifax, E McKeown, P Sivakumar, I Fairbairn, C Peter, A Leitch, ...

The Lancet 396 (10243), 39-49

Randomised Trial for Ambulatory Management of Primary Spontaneous Pneumothorax">Randomised Trial for Ambulatory Management of Primary Spontaneous Pneumothorax

R Hallifax, E McKeown, P Sivakumar, I Fairbairn, C Peter, A Leitch, ...

A24. EPIDEMIOLOGY, DIAGNOSIS, AND TREATMENT IN PLEURAL DISEASE AND IP, A1124 …

What is the efficacy and safety of rapid exercise tests for exertional desaturation in covid-19">What is the efficacy and safety of rapid exercise tests for exertional desaturation in covid-19

T Greenhalgh, B Javid, M Knight, M Inada-Kim

Centre for Evidence-Based Medicine, Nuffield Department of Primary Care …

What is the efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: A rapid review protocol">What is the efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: A rapid review protocol

T Greenhalgh, B Javid, M Knight, M Inada-Kim

The Rocket Pleural Vent in Pneumothorax">The Rocket Pleural Vent in Pneumothorax

M Knight, P Yunger, Z Wu, A Barlow

European Respiratory Journal 54 (suppl 63)

S99 Point of care testing for respiratory viruses (RPOCT): a novel service to facilitate appropriate discharge and infection control measures and improve antimicrobial stewardship">S99 Point of care testing for respiratory viruses (RPOCT): a novel service to facilitate appropriate discharge and infection control measures and improve antimicrobial stewardship

K Roy, K Groom, N Read, C Cucciniello, M Knight

Thorax 73 (Suppl 4), A60-A61

Respiratory viral point of care testing (POCT) allows improved infection control and bed management during an influenza outbreak">Respiratory viral point of care testing (POCT) allows improved infection control and bed management during an influenza outbreak

K Roy, H Kandil, M Knight, M Thapa, K Groom

European Respiratory Journal 52 (suppl 62)

Point of care respiratory viral testing (POCT): A novel service to target appropriate antimicrobial prescription and improve antibiotic stewardship">Point of care respiratory viral testing (POCT): A novel service to target appropriate antimicrobial prescription and improve antibiotic stewardship

K Roy, K Groom, M Knight

European Respiratory Journal 52 (suppl 62)

The role of a pleural service in optimising pleural disease management">The role of a pleural service in optimising pleural disease management

M Knight, L Yazbeck, S Hanger, O Butters, D Creer

European Respiratory Journal 44 (Suppl 58)

The effect of bisphosphonates on calcium and parathyroid hormone levels in patients with primary hyperparathyroidism over 2 years">The effect of bisphosphonates on calcium and parathyroid hormone levels in patients with primary hyperparathyroidism over 2 years

MJ Knight, PJ Hyatt

Endocrine Abstracts 12

¿ Cuál es la eficacia y seguridad de las pruebas rápidas de ejercicio para la desaturación por esfuerzo en covid-19?">¿ Cuál es la eficacia y seguridad de las pruebas rápidas de ejercicio para la desaturación por esfuerzo en covid-19?

B Javid, M Knight, M Inada-Kim

What is the efficacy and safety of rapid exercsie tests for exertional desaturation in covid-19?">What is the efficacy and safety of rapid exercsie tests for exertional desaturation in covid-19?

T Greenhalgh, B Javid, M Knight, M Inada-Kim

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Proof that virtual clinics can reduce waiting lists - HSJ opinion ">Proof that virtual clinics can reduce waiting lists - HSJ opinion 

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A Virtual hospital model can help tackle the Covid pandemic">A Virtual hospital model can help tackle the Covid pandemic - HSJ opinion

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https://www.telegraph.co.uk/news/2020/05/24/coronavirus-patients-monitored-year/

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https://www.telegraph.co.uk/health-fitness/body/everything-doctors-know-far-treating-coronavirus/ 

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https://www.hemeltoday.co.uk/health/coronavirus/watford-general-treated-hundreds-covid-19-patients-virtual-hospital-2907125 

https://www.thehtn.co.uk/2020/06/12/huma-supports-nhsx-remote-monitoring-trials/

https://www.med-technews.com/news/virtual-wards-created-for-remote-monitoring-of-covid-19-pati/

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https://www.forbes.com/sites/davidprosser/2020/06/19/huma-proves-the-case-for-digital-health-amid-covid-19-crisis/

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https://www.nhsx.nhs.uk/blogs/early-data-nhsx-tech-enabled-remote-monitoring-pilot/

Clinical Trials

https://www.southampton.ac.uk/medicine/academic_units/projects/cerabtc-19.page

https://www.southampton.ac.uk/medicine/academic_units/projects/cerrnatc-19.page

https://www.southampton.ac.uk/medicine/research/projects/covid-19-virtual-hospital-prognostic-study-covpro.page?#project_overview%0A____________________

https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/predict-covid-uk-the-development-of-a-risk-scoring-tool-for-covid-19-covid-19/

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http://www.isrctn.com/ISRCTN79151659 RAMPP study

(Randomised ambulatory management of primary pneumothorax)

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http://www.isrctn.com/ISRCTN79956557?q=&filters=conditionCategory:Respiratory&sort=&offset=4&totalResults=672&page=1&pageSize=10&searchType=basic-search

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HiSPEC trial – The use of an ambulatory device in the treatment of pneumothoraces caused by underlying lung disease